期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：10
页码：2757-2761
DOI：10.1073/pnas.70.10.2757
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：It was previously proposed, primarily on the basis of evidence in vitro, that L-threonine deaminase, the ilvA gene product, is required for repression of its own synthesis and for repression of the other genes in the ilv-ADE operon. In this communication, evidence in vivo is presented that supports this autoregulatory model. Further evidence is presented that suggests that L-threonine deaminase is also required for induction of the ilvC gene product. The autoregulatory model is presented in an expanded form to include recent evidence that L-threonine deaminase (EC 4.2.1.16 ) is a central element for repression of the ilvADE and ilvB operons, and for induction of the ilvC operon.
