期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：1
页码：89-92
DOI：10.1073/pnas.71.1.89
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Proteins L7 and L12 from 50S ribosomal subunits of Escherichia coli are required for peptidechain termination. This termination process is inhibited by thiostrepton. Since both thiostrepton-treated ribosomes and those depleted of L7 and L12 have a markedly reduced ability to form release factor{middle dot}UA[3H]A{middle dot}ribosome complexes, the binding of release factors to the ribosome appears to be the primary site of inhibition.
