期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：1
页码：237-241
DOI：10.1073/pnas.71.1.237
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The constitutive production of small amounts of trpB enzyme in an Escherichia coli strain carrying {lambda}cI857 prophage within the trpC gene has been examined in derivatives of this strain from which portions of the prophage have been deleted. Enzyme production requires a site (pI) within the prophage close to the left prophage end. Selection for mutants of this lysogen that grow on low concentrations of indole yielded two types of mutations within the prophage: (a) v2-type, in which all phage genes controlled by the major leftward operator are derepressed; and (b) int-c type, in which the only phage gene derepressed is int. The int-c mutations lie in the same part of the prophage as pI. All int-c mutants appear deficient in xis gene function, even when derepressed.
