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  • 标题:Membrane Molecules Determined by the H-2 Associated Immune Response Region: Isolation and Some Properties
  • 本地全文:下载
  • 作者:S. E. Cullen ; C. S. David ; D. C. Shreffler
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1974
  • 卷号:71
  • 期号:3
  • 页码:648-652
  • DOI:10.1073/pnas.71.3.648
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Membrane associated molecules that are probably glycoproteins could be specifically precipitated from NP-40 detergent solubilized extracts of radiolabeled mouse spleen or lymph node cells by antisera produced in congenic strain combinations differing only in the Ir gene region which is linked to the H-2 genes. These Ir region products were designated Lna (lymph node antigen) to conform to previous serological work. Sodium dodecyl sulfate--polyacrylamide gel electrophoresis of unreduced specific immune precipitates revealed the presence of a possible dimer form, while reduced samples showed only a single peak equivalent to 30,000 daltons. Thus the Lna molecules are clearly distinct from the H-2D and H-2K molecules, which are about 45,000 daltons. Anti-Lna antibodies of different specificity can be present in a single serum; there were at least two separate antigen molecules present in one haplotype tested.
  • 关键词:histocompatibility ; transplantation antigens
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