期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：6
页码：2251-2255
DOI：10.1073/pnas.71.6.2251
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A total of 40 mouse-human cell hybrids were induced with poly(I){middle dot}poly(C) and with Newcastle disease virus. Ten hybrid clones produced low levels of human interferon in response to both the virus and poly(I){middle dot}poly(C). Concurrent enzymic and chromosomal analysis of the hybrid clones indicated a concordant segregation of these levels of human interferon with chromosomes 2 and 5. The presence of both chromosomes 2 and 5 was necessary for interferon production; neither was sufficient alone. Based on this finding, we postulate that there are at least two asyntenic gene loci for the expression of interferon in human cells.
