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  • 标题:Prolongation of the Life-Span in Mice Adapted to Large Amounts of L-Dopa
  • 本地全文:下载
  • 作者:George C. Cotzias ; Samuel T. Miller ; Alexander R. Nicholson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1974
  • 卷号:71
  • 期号:6
  • 页码:2466-2469
  • DOI:10.1073/pnas.71.6.2466
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.
  • 关键词:adaptation ; body weight ; levodopa ; corneal opacities
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