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  • 标题:Association Between Fighting Behavior and Catecholamine Biosynthetic Enzyme Activity in Two Inbred Mouse Sublines
  • 本地全文:下载
  • 作者:Roland D. Ciaranello ; Ann Lipsky ; Julius Axelrod
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1974
  • 卷号:71
  • 期号:8
  • 页码:3006-3008
  • DOI:10.1073/pnas.71.8.3006
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Levels of three adrenal catecholamine synthesizing enzymes and isolation-induced fighting behavior were studied in two related sublines of the Balb/c inbred mouse strain. Enzyme levels were twice as high in the adrenals of Balb/cJ mice as in those of the Balb/cN mice; heterozygous progeny were intermediate between their parents in the levels of the three enzymes. These sublines also showed marked differences in their fighting behavior after a 2-week isolation period. Balb/cJ mice fought immediately after presentation of an intruder mouse, while Balb/cN mice did not fight at any time during the test. Heterozygous progeny behaved more like the Balb/cN (non-fighters). Analysis of F2 mice suggested that the differences in fighting behavior were determined by a single gene, with fighting being recessive.
  • 关键词:genetics ; tyrosine hydroxylase ; dopamine β-hydroxylase ; phenylethanolamine N -methyltransferase ; aggressive behavior
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