期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：8
页码：2996-3000
DOI：10.1073/pnas.71.8.2996
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Treatment of vitamin D-deficient rats with Prednisolone(R) does not alter the rate of conversion of [3H]25-hydroxyvitamin D3 to [3H]1,25-dihydroxyvitamin D3, but the further conversion of [3H]1,25-dihydroxyvitamin D3 to a more polar metabolite is more rapid in the Prednisolone(R)-treated animals. This more polar metabolite is biologically inactive, periodate-insensitive, and persists in the intestine as long as 1,25-dihydroxyvitamin D3. Also, the time course of action of 1,25-dihydroxyvitamin D3 upon intestinal calcium transport is altered by Prednisolone(R) treatment. Treatment with Prednisolone(R) did not change the magnitude of the initial response to 1,25-dihydroxyvitamin D3 at 7 hr, but did decrease the response at 24 and 48 hr after a single dose of 1,25-dihydroxyvitamin D3. The present results show that one of the means by which large doses of adrenal corticoids alter intestinal calcium transport is by stimulating the further metabolism of 1,25-dihydroxyvitamin D3 to a more polar, biologically inactive intestinal metabolite.
关键词：vitamin D ; intestinal calcium absorption ; adrenal steroids
