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  • 标题:Significance of Plasma Dopamine β-Hydroxylase Activity as an Index of Sympathetic Neuronal Function
  • 本地全文:下载
  • 作者:John L. Reid ; Irwin J. Kopin
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1974
  • 卷号:71
  • 期号:11
  • 页码:4392-4394
  • DOI:10.1073/pnas.71.11.4392
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Plasma norepinephrine and dopamine {beta}-hydroxylase (EC 1.14.17.1 ) activity were measured in rats. Adrenergic neuron blockade with bretylium for 4 hr and ganglion blockade with chlorisondamine for 72 hr lowered plasma norepinephrine. Neither treatment altered plasma dopamine {beta}-hydroxylase activity. Phenoxybenzamine for up to 48 hr markedly raised plasma norepinephrine and transiently lowered plasma dopamine {beta}-hydroxylase at 24 hr. Prolonged pharmacological modification of sympathetic nervous activity and plasma norepinephrine were not attended by parallel changes in circulating dopamine {beta}-hydroxylase activity. Plasma dopamine {beta}-hydroxylase activity does not appear to be a sensitive index of prolonged alterations in sympathetic neural activity. Norepinephrine in plasma, however, appears to reflect sensitively and accurately the rate of release of the neurotransmitter.
  • 关键词:norepinephrine ; adrenergic neuronal blockade ; bretylium ; chlorisondamine ; phenoxybenzamine
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