期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：12
页码：4693-4697
DOI：10.1073/pnas.71.12.4693
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Aspirin acetylates a variety of sites on both the [α] and {beta} chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: {beta}Lys 59, {beta}Lys 144, and [α]Lys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.
