期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1975
卷号：72
期号：4
页码：1291-1295
DOI：10.1073/pnas.72.4.1291
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Over a long time period, the rate constants for cycle completions (one-way fluxes) in steady-state biochemical diagrams can be expressed explicitly in terms of the elementary rate constants for transitions between states of the diagram. These cycle rate constants determine the mean one-way fluxes in the diagram and also fluctuations about the means. These properties are confirmed by Monte Carlo computer simulations on special cases. Two other topics are considered briefly: the effect of the starting state or states on the numbers of cycle completions in computer simulation runs; and the more detailed stochastic approach required if individual cycle completions are to be followed (i.e., if the "long time" restriction is removed).
