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  • 标题:Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system
  • 本地全文:下载
  • 作者:M N Thang ; D C Thang ; E De Maeyer
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1975
  • 卷号:72
  • 期号:10
  • 页码:3975-3977
  • DOI:10.1073/pnas.72.10.3975
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse cells; (2) its antiviral activity was species specific; (3) its activity was completely neutralized by mouse anti-interferon serum. The synthesis of interferon in this cell-free system requires the presence of spermine.
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