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  • 标题:Activation of an endogenous mouse type C virus by ultraviolet-irradiated herpes simplex virus types 1 and 2
  • 本地全文:下载
  • 作者:B Hampar ; S A Aaronson ; J G Derge
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1976
  • 卷号:73
  • 期号:2
  • 页码:646-650
  • DOI:10.1073/pnas.73.2.646
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Infection of BALB/c mouse cells with UV-irradiated herpes simplex virus (HSV) types 1 and 2 resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat-inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3-4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.
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