期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1976
卷号：73
期号：4
页码：1351-1354
DOI：10.1073/pnas.73.4.1351
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：K+ potentials were investigated using K+ microelectrodes in frog (Rana pipiens) retinas conditioned for spreading depression (SD) by Cl--free Ringer's solution. A marked increase in outside K+ concentration, [K+]O, maximal in the inner plexiform layer, was observed during SD. This [K+]o change resembled the simultaneously recorded membrane potential change in Muller cells, suggesting that these cells act as K+ electrodes. Intracellular recording with K+ electrodes in Muller cells showed that upon SD the [K+]i (inside) of Muller cells increases and therefore immediately starts to cleanse the extracellular space of the excess of K+ which, evidence suggests, is mainly caused by pathologically enhanced synaptic activity in the inner plexiform layer.
