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  • 标题:Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry
  • 本地全文:下载
  • 作者:S Mabrey ; J M Sturtevant
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1976
  • 卷号:73
  • 期号:11
  • 页码:3862-3866
  • DOI:10.1073/pnas.73.11.3862
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:High sensitivity differential scanning calorimetry is applied to the study of the thermotropic behavior of mixtures of synthetic phospholipids in multilamellar aqueous suspensions. The systems dimyristoylphosphatidylcholine dipalmitoylphosphatidylcholine, and dimyristoylphosphatidylethanolamine-distearoylphosphatidylcholine, although definitely nonideal, exhibit essentially complete miscibility in both gel and liquid crystalline states, while the system dilauroylphosphatidylcholine-distearoylphosphatidylcholine is monotectic with lateral phase separation in the gel state. Comparison of the observed transition curves with theoretical curves calculated from the calorimetrically determined phase diagrams supports a literal interpretation of the phase diagrams.
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