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  • 标题:Embryonal carcinoma antigen and the T/t locus of the mouse
  • 本地全文:下载
  • 作者:R Kemler ; C Babinet ; H Condamine
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1976
  • 卷号:73
  • 期号:11
  • 页码:4080-4084
  • DOI:10.1073/pnas.73.11.4080
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The presence of the F9 antigen and of four other antigens related to the T/t locus of the mouse was investigated by immunofluorescence on preimplantation embryos. In morulae heterozygous for any of these t haplotypes, both the appropriate t antigen and the F9 antigen are expressed. The F9 antigen segregates among the progeny of crosses producing embryos homozygous for some (tw32 and tw5) but not for other haplotypes. It is concluded that (i) whatever the time of action of a t haplotype, its corresponding antigen is expressed during cleavage and (ii) the F9 antigen is specified by a gene(s) in the region of the T/t locus.
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