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  • 标题:Uncouplers and the molecular mechanism of uncoupling in mitochondria
  • 本地全文:下载
  • 作者:R J Kessler ; H Vande Zande ; C A Tyson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1977
  • 卷号:74
  • 期号:6
  • 页码:2241-2245
  • DOI:10.1073/pnas.74.6.2241
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The molecular mechanism of uncoupling sheds strong light on the mechanism of coupling.
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