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  • 标题:Cholinergic metabolism and synapse formation by a rat nerve cell line
  • 本地全文:下载
  • 作者:D Schubert ; S Heinemann ; Y Kidokoro
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1977
  • 卷号:74
  • 期号:6
  • 页码:2579-2583
  • DOI:10.1073/pnas.74.6.2579
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The PC12 clone of a rat pheochromocytoma is able to synthesize acetylcholine. The amount of acetylcholine synthesized, and the specific activity of choline O-acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6 ), varies as a function of the culture growth curve and is dependent on cell density. The specific activity of choline acetyltransferase is increased by nerve growth factor, growth-conditioned medium from a variety of cell types, and adenosine 3':5'-monophosphate. Finally, the PC12 cell line is able to form cholinergic synapses with a clonal cell line of skeletal muscle origin.
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