期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1978
卷号：75
期号：6
页码：2868-2872
DOI：10.1073/pnas.75.6.2868
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A mathematical theory is developed that enables us to derive a formula for the equilibrium distribution of allelic frequencies in a finite population when selectively neutral alleles are produced in stepwise fashion (stepwise mutation model). It is shown that the stepwise mutation model has a remarkable property that distinguishes it from the conventional infinite allele model (Kimura-Crow model): as the population size increases indefinitely while the product of the effective population size and the mutation rate is kept at a fixed value, the mean number of different alleles contained in the population rapidly reaches a plateau which is not much larger than the effective number of alleles (reciprocal of homozygosity).
