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  • 标题:Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I
  • 本地全文:下载
  • 作者:W J Grossman ; J T Kimata ; F H Wong
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1995
  • 卷号:92
  • 期号:4
  • 页码:1057-1061
  • DOI:10.1073/pnas.92.4.1057
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.
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