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  • 标题:Bayesian Nonparametric Model for Clustering Individual Co-exposure to Pesticides Found in the French Diet
  • 本地全文:下载
  • 作者:Amelie Crepet ; Jessica Tressou
  • 期刊名称:Bayesian Analysis
  • 印刷版ISSN:1931-6690
  • 电子版ISSN:1936-0975
  • 出版年度:2011
  • 卷号:06
  • 期号:01
  • DOI:10.1214/11-BA604
  • 出版社:International Society for Bayesian Analysis
  • 摘要:

    This work introduces a speci c application of Bayesian nonparamet-
    ric statistics to the food risk analysis framework. The goal was to determine the
    cocktails of pesticide residues to which the French population is simultaneously
    exposed through its current diet in order to study their possible combined e ects
    on health through toxicological experiments. To do this, the joint distribution of
    exposures to a large number of pesticides, which we called the co-exposure distri-
    bution, was assessed from the available consumption data and food contamination
    analyses. We propose modelling the co-exposure using a Dirichlet process mixture
    based on a multivariate Gaussian kernel so as to determine groups of individuals
    with similar co-exposure patterns. Posterior distributions and optimal partition
    were computed through a Gibbs sampler based on stick-breaking priors. The study
    of the correlation matrix of the sub-population co-exposures will be used to de ne
    the cocktails of pesticides to which they are jointly exposed at high doses. To
    reduce the computational burden due to the high data dimensionality, a random-
    block sampling approach was used. In addition, we propose to account for the
    uncertainty of food contamination through the introduction of an additional level
    of hierarchy in the model. The results of both speci cations are described and
    compared.

  • 关键词:Dirichlet process; Bayesian nonparametric modeling
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