摘要：Dengue Virus (DV) infection causes life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. We are the first to report that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF and DSS, which is different from the profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the disease severity and to predicate the consequence of DV infection.
