出版社：SISSA, Scuola Internazionale Superiore di Studi Avanzati
摘要：The Italian INFN TPS project is a multi-disciplinary effort by the Istituto Nazionale di Fisica Nucleare (INFN) to develop a fully functional Treatment Planning System (TPS) for therapies using carbon ion beams with an active delivery system. This paper presents general information about the project and gives an overview of two specific tasks of the INFN Torino, respectively the biological dose optimisation and the beam modelling. An example of the biological cost function and the related results for the optimised biological dose, obtained with the conjugate gradient method applied to a basic treatment case, are given. Moreover, it is shown how the radiobiological effectiveness can be modelled through a transfer function, derived from the physical measured data, when a ripple filter is inserted along the beam line. The work has been done in collaboration with the Belgian Ion Beam Applications (IBA) company, within a research cooperation agreement.
