Background. The aim of this investigation was the analysis of primary malignant brain tumors (PMBT)-related mortality in the Belgrade population during the period 1983−2000. Methods. Mortality data (based on death records) for the period observed, as well as population data, were obtained from the unpublished material of the Municipal Institute of Statistics, Belgrade. The data analysis was adjusted to specific and standardized mortality rates and linear trend, using the world population as a standard. Regression coefficient was determined by Fisher’s test. Results. During the period 1983−2000, in the Belgrade population standardized mortality rates from PMBT were 6.29/100 000 (95%CI-confidence interval 5.33−7.24) for males, 4.50/100 000 (95%CI 3.84−5.17) for females, and 5.91/100 000 (95%CI 5.20−6.63) for total population. The age-specific mortality rates increased with age up to the age group 65−74, with the highest value of 21.21/100 000 (95%CI 16.03−26.39), and decreased in persons of 75 and more years of age. Conclusion. Mortality rates from PMBT in Belgrade had slightly increasing tendency in male (5.725+0.0592x, p=0.545), and decreasing tendency in female population (y=4.703-0.0213x, p=0.756), while statistically significant increasing mortality rate was registered only in the age group 65−74 (y=435+1.7707x, p=0.0001).