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  • 标题:Primary ovarian malignant melanoma
  • 本地全文:下载
  • 作者:Kostov Miloš ; Vukomanović-Đurđević Biserka ; Nenadić Dane
  • 期刊名称:Vojnosanitetski pregled
  • 印刷版ISSN:0042-8450
  • 出版年度:2010
  • 卷号:67
  • 期号:3
  • 页码:252-255
  • DOI:10.2298/VSP1003252K
  • 出版社:Military Medical Academy, INI
  • 摘要:

    Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  • 关键词:ovarian neoplasms; melanoma; histology; immunohistochemistry; gynecologic surgical procedures
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