The study tested reliability and construct validity of Serbian translation of Beck's Hopelessness scale on a sample of patients diagnosed as a depressive, anxious and anxious-depressive disorder. Scale was found to have a high degree of internal consistency (Cronbach alpha = 0.91). Principal component analysis, with Scree-test as the criterion of extraction, provided single factor as the best solution. Hopelessness Scale highly correlated with symptoms of depression, low self-concept and depressive automatic thoughts which the authors interpreted as the confirmation of Beck's theory. The hypothesis that hopelessness is construct specific to depression and not to anxiety is, also, confirmed.