On the basis of spatial differentiation of the natural and socio-economic factors of development, we have seen the structural characteristics of the local industry and local agriculture, as two elements of the economy of Kladovo municipality, and the importance and role of these two elements in the spatial structure of the municipality. Particular attention was devoted in the course of this research, to the possibilities of intensifying the development of the less developed parts of the area. Activation of developmental potentials is directed towards a demographic revitalization and towards the establishment of a stable and progressive social-economic-ecological area, with an identity recognizable in the region. In that sense, we examine the inter-dependence of potentials limitations and risks for a more rapid future development of the municipality of Kladovo.