The analysis of demographic factors of the studied area points to the different demographic development models. Uneven economic and regional development of industry caused the regional demographic polarization of the population of Negotin municipality. In relatively short period, the transition has caused spontaneous urbanization and deagrarization. All that influenced the faster tempo of social and demographic processes, especially the migrations towards Negotin, which led to the developmental unevenness and regional polarization to the zone of population concentration (town and the suburban areas). Contrary to the town center, there are depopulation rural areas, with outstanding economic undevelopment.