The biggest south Morava river valley and one of the biggest valleys in Serbia - the Leskovac valley represents an area which is typically agricultural. In agricultural production, wheat and maize participate with 60%, and vegetables (mostly potatoes and peppers) participate with about 16%. It is also a huge producer of fruits and vine. However, the yield of these cultures is not big. In order to get bigger yield, it is necessary to conduct a detailed analysis of these cultures growing conditions where the agro-climate studies have a significant place. The work is concerned with the characteristics of climate in Leskovac Valley and they are shown by basic climatic elements (air temperature, sunny days and precipitation) for the period from 1975 to 2000. According to then, specific agroclimatic indicators were made - the length of the vegetational period, the sum of active and effective temperatures, hydrotermic (HTK) and heliotermic (HeTK) quotient and bioclimatic index (BKI).