The basic component of GIS technology (Geographical Information Systems) is the base of graphical data, which can be used for geographical definition of spaces elements- entities. As a new, modern, technology, it has more application in different hydrological researches. In GIS creation Lepenica river basin, it was applied softwares: Micro Station, GeoMedia, Surfer 7. Map and AutoCAD. After data base creation, it was enabled for users to get different information of Lepenica river basin on the simple way. Getting data are used for creation of three thematic maps (altitude zones map, hydrographical net map and precipitation isoline map).