This paper analyses the series of annual sums of precipitation for 27 stations in Serbia for the period 1951-2010. The lowest average perennial precipitation values have been determined for stations in northern Serbia, that is, generally a reduction in precipitation is noticed from west to east of the country. Northeast, east, south and southeast show negative trend values, while a positive precipitation trend is confirmed for the rest of Serbia with the highest values in the west and southwest of Serbia. The advantage of applying the method of cumulative sums and the „bootstrapping“ in the analysis of time series in relation to the method of linear trend has been emphasized. Periods when precipitation was below average or above average for the entire analyzed period were defined. Also, a spatial differentiation of change in precipitation for the period of 60 years in Serbia has been noticed. [Projekat Ministarstva nauke Republike Srbije, br. 47007]