For an integral perception of the possibility of forecasting erosion-deposition processes and their consequences it is essential to analyze the factors of erosion and deposition. The attempt was made in the paper to analyze quantitative and qualitative impact of some of the most important factors of erosion-deposition processes. The analysis was performed through a multidisciplinary approach, on the example of the Zapadna Morava River upper basin. The methodology of research encompasses an application of the adequate knowledge from the areas of meteorology, geomorphology, hydrogeology, spatial planning, economic geography, forestry, hydrology and environmental protection. The analysis encompasses meteorological factors, terrain characteristics and anthropogenic factors. The importance of the analysis and forecasts of the investigated processes for the industry, economy, spatial planning and environmental protection was emphasized.