The Pyrrhonian arguments used by Michel de Montaigne in his essay An Apology for Raymond Sebond are presented in detail in this paper. The paper explores the reasons that have induced Montaigne to utilize them in an apparently paradoxical context of Catholic apologetics. As a consequence of the influence this essay had exerted in the Early Modern philosophy, a considerable interest has been developed for the Ancient Skepticism, notwithstanding the fact that the Skeptical arguments were not always correctly interpreted in Montaigne's work.