The analysis of influence of social-economic factors is important in the analysis of demographic development of population in Vojvodina Province. The development of each society is significantly implied with interaction of demographic and social-economic factors. In the paper the relevant indicators of demographic development of population in Vojvodina are explored. The combined data from population census and yearly published data related to communes and districts of Vojvodina were used. The estimated empirical regression models based on chosen variables, ought to illustrate the reached level of demographic development in Vojvodina Province. The relations of the following variables are analyzed: the total number of inhabitants, the number of active persons, the number of agriculturists per 100 population, the rate of employment, national income, rates of natural increase, birth and mortality etc. The authors expect that the obtained results will contribute to explain the questions concerned with the development of Vojvodina. Province.