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  • 标题:Dediscretization of distributions arising in macroevolution models
  • 本地全文:下载
  • 作者:Astola Jaakko ; Danielian Eduard
  • 期刊名称:Facta universitatis - series: Electronics and Energetics
  • 印刷版ISSN:0353-3670
  • 电子版ISSN:2217-5997
  • 出版年度:2007
  • 卷号:20
  • 期号:2
  • 页码:119-146
  • DOI:10.2298/FUEE0702119A
  • 出版社:University of Niš
  • 摘要:

    The standard birth-death process with intensities of moderate growth generates stationary skewed distributions suitable for modeling frequency distributions of events arising in large-scale biomolecular systems. We study a large class of such distributions that can be used to model, for instance frequency distributions of the number of expressed genes in the transcriptome, the number of protein domain occurrences in the proteomes etc. In the present paper a new dediscretization approach is suggested discussed and applied to the chosen class. This approach conserves the qualitative properties of the original class of distributions. The advantages of the approach consist in following: 1. It simplifies the form of distributions; 2. It allows simple mathematical analysis of the properties of the original class by applying the tools mathematical analysis continuous functions 3. It allows to find out the optimal form of stationary distributions, i.e. suggests new classes of distributions for biomolecular applications. The deviations of the dediscretized continuous distribution functions from the original distribution functions is estimated. Several typical examples are considered which illustrate the possibilities of the dediscretization approach. The reverse procedure to dediscretization, i.e. the procedure of discretization, back to discrete distributions is described.

  • 关键词:Dediscretization; distribution; distribution function; regular variation; skewness; convexity; biomolecular systems
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