摘要：We describe a computational framework for the quantitative assessment of contractile responses of isolated neonatal cardiac myocytes. To the best of
our knowledge, this is the first report on a practical and accessible method for the assessment of contractility in neonatal cardiocytes. The proposed methodology is comprised of digital video recording of the contracting cell, signal preparation, representation by polar Fourier descriptors, and contractility assessment. The different processing stages are variants of mathematically sound and computationally robust algorithms very well established in the scientific community. The described computational approach provides a comprehensive assessment of the neonatal cardiac myocyte contraction without the need of elaborate instrumentation. The versatility of the methodology allows it to be
employed in determining myocyte contractility almost simultaneously with the acquisition of the Ca2
