期刊名称：International Journal of Mathematics and Mathematical Sciences
印刷版ISSN：0161-1712
电子版ISSN：1687-0425
出版年度：2012
卷号：2012
DOI：10.1155/2012/421419
出版社：Hindawi Publishing Corporation
摘要：A controlled SIWR model was considered which was an extension of the simple SIR model by adjoining a compartment (𝑊) that tracks the pathogen concentration in the water. New infections arise both through exposure to contaminated water as well as by the classical SIR person-person transmission pathway. The controls represent an immune boosting and pathogen suppressing drugs. The objective function
is based on a combination of minimizing the number of infected individuals and the cost of the drugs dose. The optimal control is obtained by solving the optimality system which was composed of four nonlinear ODEs with initial conditions and four nonlinear adjoint ODEs with transversality conditions. The results were analysed and interpreted numerically using MATLAB.
