首页    期刊浏览 2024年12月03日 星期二
登录注册

文章基本信息

  • 标题:Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles
  • 本地全文:下载
  • 作者:Gregory J. Zilinskas ; Abdolrasoul Soleimani ; Elizabeth R. Gillies
  • 期刊名称:International Journal of Polymer Science
  • 印刷版ISSN:1687-9422
  • 电子版ISSN:1687-9430
  • 出版年度:2012
  • 卷号:2012
  • DOI:10.1155/2012/564348
  • 出版社:Hindawi Publishing Corporation
  • 摘要:Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.
国家哲学社会科学文献中心版权所有