This study develops a conceptual model for understanding the information system quality of relationship quality and loyalty in the e-service context of shopping, and a conceptual model is also introduced. This study tries to conceptualize a model based on the mediator of relationship quality that is applied to understand loyalty in e-shopping websites. In the proposed model, loyalty is influenced by the relationship quality and information system quality. Additionally, three propositions are developed based the proposed model and literature review. Finally, conclusions, managerial implications, and future research are also provided.