The main aim of this paper is to examine the Supreme flood and its impact on poverty in rural Sindh. Data were collected from 5000 households from six districts i.e. Kashmore, Kamber Shahdadkot Shikarpur, Dadu, Larkana and Jacobabad Sindh by using the simple random technique; a structural questionnaire was design as an instrument tool for measuring the poverty. It was revealed that the poverty position in Jacobabad and Shikarpur is worsening compare with Larkana and Sukkur. There are other factors like tribal disputes among various tribes and law and order situation most of the businesses people shift their business from Jacobabad and Shikarpur. Access to health and education facilities all districts have slight variation except Jacobabad where the literacy ratio is pretty low. It was revealed that recent supreme flood hit common man and poverty level is increases because it was estimated that loss of livestock and crop loss affected he common man in the flood affected areas.