This research investigates the entrepreneurship development and employment in Khairpur Mirs. Data were collected from 2000 respondents from Khairpur Mirs and their vicinity. A structural questionnaire was developed for the reliability and validity of the data. It was revealed that Khairpur Mirs is facing unemployment problems like other states of Pakistan. The number of population increases every year but the state government cannot provide jobs to all the citizens. Unemployment gives different negative impact to the state economy in particular and the country economy in general. However, government had taken up various measures to reduce unemployment problems but it increases rather than minimising it. It was further revealed that only 3.13 percent out of total population who got employment in the state private and public sectors. This shows that the total number of employments in the state is very less. The result may be due to various factors but it is clearly concluded that the getting employment in Khairpur Mirs- Sindh-Pakistan is a problematic issue that hinder the growth of state economy.