This research investigates the cultural consequences of Karo Kari. Data were collected from 500 respondents from Jacobabad and their vicinity. A structural questionnaire was developed for the reliability and validity of the data. It was revealed that more than 500 cases of Karo Kari reported from Jacobabad District in their vicinity. It was further revealed that cultural consequences and poor literacy rate are major cause of Karo kari. The biggest challenges which they were facing they were doing all business in house, lack of marketing facilities, Karo Kari criminal activities and they were deprived from the basic rights. The number of women who died of stove burns in the first six months of 1992 was 500 compared to 570 murders that took place at the same time