摘要：Determination of anti-citrullinated peptides (anti-CCP) specificity as a predictor of joint erosive changes, correlation between their serum level and radiological damages as well as disease activity score (DAS28). A trial has been conducted on a 211 patient sample fulfilling ACR criteria for rheumatoid arthritis (RA). There was assigned anti-CCP serum level, disease activity score by the formula for DAS28(3)-CRP and assessed radiological changes degree after Steinbrocker score. In 132 patient (62,559%) the serum anti-CCP concentration was positive for RA. Specificity of the test was 100% and sensitivity 65% (Z=0,731, p=0,465). There is a medium intensity correlation between variables representing anti- -CCP and Steinbrocker score. Pearson’s coefficient was 0,479 and Spearman’s rank correlation coefficient was 0,614, i.e. statistically significant (p=0,000). There is no statistically significant correlation between variables representing anti- -CCP and DAS28(3)-CRP. Anti-CCP are good RA predictor and their concentration correlate with radiological damages degree.
