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  • 标题:Progression of Optic Neuritis to Multiple Sclerosis in the County of Split-Dalmatia, Croatia
  • 本地全文:下载
  • 作者:Bojić, Lovro ; Rogošić, Veljko ; Ivanišević, Milan
  • 期刊名称:Collegium Antropologicum
  • 印刷版ISSN:0350-6134
  • 出版年度:2007
  • 卷号:31
  • 期号:2
  • 页码:557-560
  • 出版社:Hrvatsko antropološko društvo
  • 摘要:The aim of this study was to determine the incidence of monosymptomatic optic neuritis (MON) and progression of MON to multiple sclerosis (MS) from the Mediterranean region of southern Europe in the County of Split-Dalmatia, Croatia during the 11 years period from 1991 to 2001. This study was made retrospectively on the 87 cases (59 female, aged 25.9±11.3 and 28 male aged 29.9±9.2) of MON, which were treated at the Department of Ophthalmology and Department of Neurology, Split, University Hospital, from January 1991 to December 2001. In each case the diagnosis was confirmed by a chart review and cases were ascribed to the data of admittance at hospital. The annual incidence of MON was 1.9 per 100,000 (95% CI, 0.4–3.5). The incidence among males was 1.2 (95% CI, 0–2.9) cases / 100,000 per year and 2.5 (95% CI, 0.1–4.9) among females. A significant seasonal variations in the incidence of MON was not found (c 2=6.81, p=0.08). MS developed in 20 of 87 patients (22.9%) and median time was 25 (SE 8) months, (95% CI, 9–41) after the MON onset. After two years 12.6% of patients with MON developed MS, 20.6% after 5 years and 22.9% after 10 years. MS was slightly but not significantly more frequent in women than in men (c 2 =0.72, p=0.3). In conclusion, the progression of MON to MS in the County of Split-Dalmatia, Croatia was at a relatively moderate frequency.
  • 关键词:optic neuritis; multiple sclerosis; incidence; progression
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