摘要：We studied IL-1 level in corneal scars with/without neo-vascularization. A total of 27 patients underwent grafting for corneal scar. Recipients were grouped according to number of vascularized quadrants (0 to IV/IV): none (n=12), one (n=5), two (n=4) and four (n=6). Recipient corneas were collected during surgery and IL-1 measured by immunoassay. Controls were donor corneas unsuitable for transplantation. Graft rejection rate was calculated for each group. Mean IL-1 concentration in corneal scars was 63.93 pg/mm3; significantly higher as compared to controls (1.25 2.03 pg/mm3). IL-1 correlated well with amount of blood vessels, except in IV/IV scars: 5.173.65 pg/mm3 for 0/IV; 8.022.51 pg/mm3 for I/IV; 8.273.62 pg/mm3 for II/IV and 4.475.03 pg/mm3 for IV/IV corneal scars. Vascularization of corneal scar is associated with increased IL-1 level (in all but highly vascularized scars), indicating that IL-1 promotes early stages of vascularization. Graft rejection rate increases in patients with higher vascularization, independently of IL-1 level.
