摘要：Health Canada has identified the need for a standardized department‐wide approach for the risk assessment of carcinogens in foods (e.g., pesticides, food chemical contaminants, veterinary therapeutics). A standardized approach would better facilitate and inform risk management strategies for the control of human exposure to food sources of carcinogens. Within the post‐ market regulatory context, directly DNA‐reactive carcinogens are of most concern because any exposure is theoretically assumed to be associated with a risk of producing a carcinogenic effect in proportion to the dose. Such non‐threshold carcinogens, as well as carcinogens in which a non‐linear dose response has not been demonstrated, require different approaches for risk characterization. In order to contribute to Health Canada’s department‐wide discussions regarding the development of risk management strategies for carcinogens, a general overview was conducted on international approaches for post‐market risk assessments of carcinogenic contaminants in food. In this review, areas in the risk assessment paradigm which are identified for development of further standardized guidance include the weight‐of‐evidence determination for whether a compound should be considered a non‐threshold carcinogen, the technical criteria for choosing the appropriate dose‐response assessment approach, and a consistent approach for interpreting and prioritizing risk
