We develop a timed calculus for Mobile Ad Hoc Networks embodying the peculiarities of local broadcast, node mobility and communication interference. We present a Reduction Semantics and a Labelled Transition Semantics and prove the equivalence between them. We then apply our calculus to model and study some MAC-layer protocols with special emphasis on node mobility and communication interference. A main purpose of the semantics is to describe the various forms of interference while nodes change their locations in the network. Such interference only occurs when a node is simultaneously reached by more than one ongoing transmission over the same channel.