期刊名称：The Journal of Health, Population and Nutrition
印刷版ISSN：1606-0997
电子版ISSN：2072-1315
出版年度：2009
卷号：27
期号：5
页码：640-645
出版社：International Centre for Diarrhoeal Disease Research Bangladesh
摘要：Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing
for the treatment of sepsis. The study was conducted to evaluate the pharmacokinetics of gentamicin for
the treatment of neonatal sepsis in predetermined doses at 24- or 48-hour intervals, according to weight
category, and to develop a simplified protocol for use in peripheral healthcare settings in developing countries.
This prospective observational study was conducted among 59 neonates admitted to the Special Care
Nursery at Dhaka Shishu Hospital, Bangladesh, with suspected sepsis and treated with antibiotics, including
gentamicin. Intravenous dosing of gentamicin according to weight category was: 10 mg every 48 hours
if the infant weighed 12 μg/mL in 28.8% and initial trough concentration was >2 μg/mL in 6.8% of the
subjects. No signs of nephrotoxicity or ototoxicity were detected. Favourable pharmacokinetic parameters
found with the simplified dosing regimen suggest that it is safe for the treatment of neonatal sepsis.
