The paper presents analysis of spatial and demographic changes in the settlement network of Zmijanje, which are observed in territorial depopulation i.e. in several decades of demographic (population) decline and fragmentation of settlements. These negative trends of population growth are particularly evident in the highland and mountainous areas - in the settlement networks in the Republic of Srpska and the settlement network of Zmijanje, peripheral regions, and the remote areas, away from the local, subregional and regional centres, etc. [Projekat Ministarstva nauke Republike Srbije, br. 176017]