This work evaluated the potential of hydrotalcites based in Ca-Al on trasesterification of soybean oil with ethanol. The reaction was carried out at 78.5 °C with ethanol:oil molar ratio of 30 and 10 wt% of catalyst. The 2Ca-Al showed better performance than 3Ca-Al catalyst achieving conversion of 94%. The catalyst were characterized with XRD, BET and activity was evaluated on isopropanol decomposition reaction.